rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common variants in the MTHFR gene (C677T and A1298C) have been associated with reduced enzyme activity, thereby making MTHFR polymorphisms a potential candidate as a cancer-predisposing factor.
|
17712558 |
2007 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multiplex PCR for simultaneous detection of 677 C-->T and 1298 A-->C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk.
|
12175537 |
2002 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Accumulating evidence has indicated that two common genetic variants, C677T and A1298C, are associated with cancer risk.
|
20002681 |
2010 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions were observed between the MTHFR A1298C polymorphism and bowel habits, family history of cancer, alcohol consumption, and beef consumption on colon cancer risk (P-value for interaction = 0.0005, 0.007, 0.067, 0.003, respectively).
|
20551579 |
2010 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common methylenetetrahydrofolate reductase gene variants (MTHFR C677T and A1298C) have been described to have opposite effects on cancer patients.
|
17488658 |
2007 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR variants may cause genomic hypomethylation, which may lead to the development of cancer, and MTHFR gene polymorphisms (especially C677T and A1298C) are known to influence predispositions for cancer development.
|
26745044 |
2015 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer.
|
21732284 |
2011 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our objective was to evaluate the MTHFR C677T-A1298C polymorphisms in patients with breast cancer and in individuals with no history of cancer, to compare the levels of genetic damage and apoptosis under folic acid (FA) deficiency between patients and controls, and to assess associations with breast cancer.
|
22901194 |
2012 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, the mutant C allele of MTHFR A1298C was significantly higher in the cancer group than in the normal group.
|
29740106 |
2018 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer.
|
16777985 |
2006 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer.
|
22194208 |
2011 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, significant association was observed between MTHFR A1298C polymorphism and cancer risk when all eligible studies were pooled into the meta-analysis.
|
26156333 |
2016 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk.
|
23076526 |
2013 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
C667T, and to a lesser extent A1298C polymorphisms, are also reported to influence the cytotoxic effect of fluoropyrimidines and antifolates providing support for their pharmacogenetic role in predicting the efficacy and the toxicity in cancer and rheumatoid arthritis patients.
|
18781847 |
2008 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The two common functional polymorphisms of MTHFR, 677 C-->T and 1298 A-->C have shown to impact several diseases including cancer.
|
20516537 |
2010 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) play an essential role in both DNA synthesis and methylation and polymorphisms in the MTHFR gene, 677C>T, 1298A>C and the MTRR gene, 66A>G, are associated with several types of malignancy.
|
19035314 |
2008 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
A retrospective comparative exploratory study on two methylentetrahydrofolate reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients.
|
24490800 |
2014 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this meta-analysis, we include 14 studies that focus on MTHFR C677T and A1298C polymorphisms in pediatric patients with malignancy.
|
28696419 |
2018 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common polymorphisms are reported, C677T and A1298C, that are implicated in a number of human diseases, including cancer.
|
25921104 |
2015 |
rs397507444
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common genetic variants, C677T and A1298C, of MTHFR are associated with number of human diseases, including cancer, as well as being involved in the modulation of therapy outcome to antifolate drugs.
|
24533714 |
2014 |